STUDY STATUS: ACTIVE!
Patients included in DISCO
17th May 2022
Although the majority cardiac arrest patients who regain circulation don´t have ECG changes that indicate an acute STEMI (ST-elevation myocardial infarction), registry studies have shown that about 30% of these patients have an acute occlusion, sub-occlusion or signs of an occlusion of any coronary artery.
Results from observational studies suggest that acute coronary angiography and percutaneous Coronary Intervention (PCI) increases survival in this group of patients . Data from randomized trials are missing however.
The overall aim of this prospective, randomized study is to investigate whether acute coronary angiography (within 120 minutes) with a predefined strategy for revascularization, is safe to implement in patients with out of hospital cardiac arrest.
A further aim of the study is to answer the important clinical question at issue; if early revascularization in this population may improve survival.
The primary question at issue is whether early angiography (within 120 minutes) with a predefined strategy for revascularization with PCI is safe to carry out in this group of patients. This will be compared with a control group who will be treated according to standard practice with coronary angiography with possible subsequent intervention according to the current routine, which usually does not occur within the first three days after cardiac arrest.
The secondary questions of issue intend to provide information which aims to answer whether this treatment strategy increases survival and improves neurological function in cardiac arrest patients who do not have signs of STEMI in acute ECG.
Our aim is to include 1006 patients in this study.
In cooperation with: